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This is one of the primary mechanisms behind appetite suppression

This is not a workaround that applies to everyone, but it is a legitimate clinical option for patients whose primary diagnosis supports it

The biological effects of activated 1,25(OH)D are mediated via its ligand-activated nuclear receptor, the VDR, which is broadly expressed across tissues and particularly enriched in skin cells

Its use in adults for anti-ageing, body composition, or weight management purposes falls entirely outside licensed indications in the UK, and the MHRA has issued warnings about unlicensed peptide hormones being sold online

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