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INTRODUCTION Diabetes is a critical global health concern due to its high prevalence[1], as well as related disability and mortality[2]

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the two large null dementia-prevention trials ( GEM , JAMA 2008 and GuidAge , Lancet Neurology 2012)

Diabetes 67 , 26012614 (2018)

AoU: All of Us, ATLAS: UCLA-Atlas Biobank, BioMe: BioMe Biobank, ESTBB: Estonian Biobank, HUS: Helsinki University Hospital, MGBB: Mass General Brigham Biobank, QBB: Qatar Biobank, UKBB: UK Biobank, AFR: African, AMR: admixed American, EAS: East Asian, EUR: European, MID: Middle Eastern, SAS: South Asian