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Many of the committee members who voted against emideltide claimed that the drug lacked significant data around safety and effectiveness

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KEAP1-dependent NRF2 activators Electrophilic compounds The most known NRF2 activators are electrophiles electron-deficient species able to form covalent bonds with electron-rich nucleophiles through a variety of chemical pathways which can covalently bind and modify cysteine residues in KEAP1 [273, 274]

Current interventions are predominantly confined to animal model validation, with limited clinical translation due to several challenges: inadequate molecular targeting efficiency, suboptimal delivery system performance, and unresolved multi-target synergistic mechanisms

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