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The primary functions of COX-1 are to maintain the integrity of the gastric mucosa and to control gastric blood flow and acid secretion, whereas COX-2 enzyme activated during an inflammatory response upregulates prostaglandin synthesis at the location of ulceration (Mizuno et al

If the molecule is broken back down into its three component amino acids, it loses its "master antioxidant" status and becomes just another protein source

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