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Curcumin and green tea extract are usually safe in food, but at higher supplement doses, both have been linked to rare cases of liver toxicity, with green tea extract raising particular concerns," says Kumar

Certain individuals are more likely to develop B12 deficiency, including those with: Pernicious anemia Gastrointestinal conditions (such as Crohns disease or celiac disease) A history of gastrointestinal surgery Difficulty absorbing nutrients due to age or other medical conditions For these patients, vitamin B12 injections are an effective option because they deliver the nutrient directly into the bloodstream, bypassing the digestive system and ensuring optimal absorption

However, these effects on motility are not limited to the upper GI tract

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Prices do not increase as your dose increases over time