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Infections Pneumonia Viral illness Sepsis Clinical Features Neonates: Neonatal jaundice (can be severe) Older children & adults: Sudden jaundice Dark tea-colored urine Fatigue, tachycardia Pallor Abdominal/back pain Hemolytic crisis after trigger exposure Confirmatory Test: G6PD enzyme assay (performed after hemolysis episode resolves) Pathognomonic Cells Heinz bodies denatured hemoglobin Bite cells result of splenic macrophage removal of Heinz bodies Management During Acute Hemolysis: Stop triggering drug/food Hydration Oxygen Treat infection Blood transfusion (if severe) Phototherapy/exchange transfusion in neonates Long-Term: Avoid triggers Vaccinations Genetic counseling Complications Acute hemolytic anemia Neonatal hyperbilirubinemia kernicterus Gallstones (pigment stones) Quick Mnemonic FAVISM F Fava beans A Aspirin / Antibiotics V Viral infections I Inherited X-linked S Sulfonamides M Malaria drugs (primaquine) Understanding G6PD Deficiency: Causes, Symptoms, and Management Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency: What is G6PD Deficiency

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