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It may cause side effects, including nausea, constipation, headache, dry mouth, numbness, tingling, and cognitive slowing

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Deshpande, A., Irani, N., Balkrishnan, R., & Benny, I

Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials