Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation
However, some patients report slight differences in how the injection feels, injection site reactions, and post-injection side effect patterns when changing formulations
Wakamatsu K, Nakao K, Tanaka H, Kitahori Y, Tanaka Y, Ojika M, Ito S (2019) The oxidative pathway to dopamine-protein conjugates and their pro-oxidant activities: implications for the neurodegeneration of Parkinsons disease
Intracellular ROS accumulation increases unstable iron and lipid peroxidation deposition through AMPK/NCOA4-mediated ferritinophagy, ultimately leading to ferroptosis and dysfunction in rat BMSCs
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