Zarrintaj P, Manouchehri S, Ahmadi Z, Saeb MR, Urbanska AM, Kaplan DL, Mozafari M
Contraindications: Who Shouldnt Use Semaglutide Semaglutide is contraindicated in specific populations: Personal or family history of medullary thyroid carcinoma (MTC) Multiple endocrine neoplasia syndrome type 2 (MEN 2) Previous serious hypersensitivity to semaglutide Pregnancy (should be discontinued at least two months before planned pregnancy) History of pancreatitis Severe gastrointestinal disease Diabetic retinopathy Kidney disease Depression or suicidal behavior: Providers monitor for new or worsening depression or suicidal thoughts and treatment should be discontinued if these symptoms develop Please note that it's highly important to discuss your health history with your healthcare provider before taking a GLP-1, especially if any of the above apply to you
In patients treated with antidepressants, there is an increase in the levels of BDNF mRNA (260) and a reversion of the decrease in CREB levels seen in patients with depression (261), which could be mechanisms of action in mood disorders (262)
This shift often leads to: Increased fat storage, particularly around the abdomen Slower metabolism Mood swings, poor sleep, and low energyall of which can make lifestyle changes more difficult By restoring hormonal balance, HRT can improve overall well-being and make weight loss more achievable
Never combine the semaglutide glycine B12 blend with any other GLP-1 receptor agonist, including Ozempic, Wegovy , liraglutide, or tirzepatide
