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Moreover, increased cellular uptake of Zn 2+ through the upregulation of zinc transporter ZIP8 activates metal-regulatory transcription factor-1 (MTF1), which in turn induces the expression of matrix-degrading enzymes in chondrocytes 33,83

USA 95 , 79877992 (1998)

It has an essential role in targeting various pathways like phosphoinositide-3-kinaseprotein kinase B/Akt (PI3K/AK), which is another pathway of curcumin to implement its influence on cancer cells, thus suppressing proliferation (Sadoughi et al., 2022)

These reactions are usually minor and resolve within hours to days