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The consistency of these signals across analytical and computational approachesincluding differential statistics, pathway analysis, and ML-based feature selectionas well as across complementary metabolomics platforms, supports the robustness of the identified signatures and reduces the likelihood of platform or method-specific effects

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For a more detailed discussion of calcium and kidney stones, see the Integrative Interventions section

Experimental animals A total of 48 Kun-Ming strain male mice were used