Side Effect Risk by Dosage: The safety margin is remarkably wide
Andrologia 50(3):e12933 Sapanidou V, Taitzoglou I, Tsakmakidis I, Kourtzelis I, Fletouris D, Theodoridis A, Lavrentiadou S, Tsantarliotou M (2016) Protective effect of crocetin on bovine spermatozoa against oxidative stress during in vitro fertilization

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These sources include peer-reviewed studies and information from agencies such as the FDA and USDA, and the National Academy of Medicine
IV glutathione caused adverse events in 32% of patients, including hepatotoxicity and anaphylaxis