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Both the EPAC2 and PKA are activated in response to elevated cAMP [54]

Braz J Pharm Sci 55:e18311 Maniaci A, La Via L, Lechien J, Sangiorgio G, Iannella G, Magliulo G, Pace A, Mat Q, Lavalle S, Lentini M (2024) Hearing loss and oxidative stress: a comprehensive review

10.2147/JIR.S498775 40 GuoJ.HuangM.HouS.YuanJ.ChangX.GaoS.et al (2024)

Hexarelin activates the CD36 scavenger receptor on cardiac myocytes, triggering a pro-survival signaling cascade including PI3K/Akt activation, increased Bcl-2 (anti-apoptotic protein), and reduced caspase-3 activity

Classification of antioxidants used in CAP Antioxidants used as adjuvant therapy in the treatment of CAP and which serve an important function in reducing the detrimental effects of ROS of both endogenous and exogenous sources as shown in Fig