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VEGF also regulates and shapes immunosuppressive TME by inhibiting dendritic cell maturation, preventing antigen presentation, and by polarizing macrophages toward an M2 phenotype

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Cycle guidelines Cycle guidelines Approach Phase 2 reference Duration 48 weeks Review Point Every 4 weeks at each dose step Best For Matches the original NEJM trial structure Approach Phase 3 TRIUMPH reference Duration 68-72 weeks Review Point Every 4 weeks