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In susceptible individuals, the hydroxylamine metabolite is unable to be detoxified leading to a cascade of cytotoxic and immunological events that eventually results in the adverse reaction

Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells

[11] Your prescriber will individualize both the route (IV or IM) and the timetable based on your weight, kidney function, and overall clinical picture