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showed that AS-IV activates the PI3K/AKT/Nrf2/ARE signaling pathway, enhancing Nrf2 expression and nuclear translocation, binding to the ARE upstream, and increasing downstream antioxidant protein expression (e.g., Ho-1, Gpx-1, Gclc, and Gclm), which mitigates oxidative stress in glomerular mesangial cells (GMCs) induced by high glucose

Enko D, Zelzer S, Niedrist T, et al

doi: 10.1002/ana.410350418

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