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Notably, non-peptide small-molecule agonists of the GLP-1R are also being developed for oral bioavailability (Mapelli et al., 2009

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[39] Amirato, G.R., Borges, J.O., Marques, D.L., Santos, J.M.B., Santos, C.A.F., Andrade, M.S

Prior to 2023, the FDA approved weightloss drugs including phentermine, topiramate, and lorcaserin [43]

Regarding presenting symptoms, jaundice and pruritis are most commonly seen, though many patients are asymptomatic and hepatic abnormalities are only incidentally found on bloodwork