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This hypothesis is consistent with a previous study that showed that individuals with BD could maintain average brain concentrations of high-energy compounds at rest, but there is an underlying abnormality in the mechanism that generates new ATP, which can be uncovered when energy demand is increased (72)

Establishing standardized PRP preparation and administration protocols are necessary to optimize its effectiveness

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Based on the selected literature, we summarize the pathogenic mechanisms of DKD and elucidate the therapeutic effects and mechanisms of bioactive substancesincluding polyphenols, peptides, polysaccharides, and flavonoidsin its treatment

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