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Transient erythema, pruritus, or stinging may develop at the application site, typically resolving with continued use or brief treatment interruption

Chronic low-grade inflammation, often called "inflammaging," is now recognized as a central driver of biological aging, contributing to cardiovascular disease, neurodegeneration, insulin resistance, and loss of muscle mass

A third reported reduced inflammation from inflammatory bowel conditions

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[84] The study published in 1957, which was conducted on "a 13-year-old male with well-documented hypopituitarism secondary to a crainiophyaryngioma," found that: "Human and monkey growth hormone resulted in a significant enhancement of nitrogen storage