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Recognizing this variation helps set realistic expectations

[DOI] [PMC free article] [PubMed] [Google Scholar] 307.Sun X, Lu Q, Yegambaram M, Kumar S, Qu N, Srivastava A, et al

Mild-to-moderate fatigue during the first 2-4 weeks is a normal adaptation response and does not indicate the medication is inappropriate

However, tirzepatides effect on gastric emptying can alter the absorption of oral medications, so timing of any oral therapies should be discussed with a provider