When combined with a balanced diet and regular physical activity, Semaglutide can induce significant weight loss, which, in turn, lowers the risk of conditions like high blood pressure and high cholesterol
Limitations of DRP assessment during the trial were the absence of assessment of retinal changes over time, while the severity was not graded on baseline
Although lifestyle interventions (low-calorie diets and exercise) are still the cornerstone of weight management, weight loss achieved through this approach is extremely difficult to sustain in the long term, particularly due to physiological adaptations that reduce the energy expended or increase appetite to compensate for the missing calories
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Importantly, weight loss with GLP-1 RAs has accompanied improvements in metabolic parameters and obesity-related comorbidities (e.g., glycemic control, lipid profiles, liver enzymes) in adolescents, mirroring findings in adults (see e.g., NASPGHAN and Endocrine guidelines)
