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TestosteroneRestoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamicsand Pharmacokinetics. [published online ahead of print,2013 Jul 12]

10.1002/jssc.201900824 92 WianowskaD.Olszowy-TomczykM

Consequently, microglia acquire a lipotoxic phenotype characterized by transcriptional up-regulation of DGAT - and ACSL -dependent lipid droplet (LD) biogenesis genes, accumulation of toxic lipids and inflammatory mediators, synaptic stripping, and memory loss

Although the enzymes of the pathway are found at multiple locations within the cell, there is as yet little convincing evidence that they operate in the apoplastic space (Foyer and Kunert 2024)

As a result, this drug can actually cause hypothyroidism, requiring the careful monitoring of TSH and Free T4 levels