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When calorie intake drops 30-50% (common on GLP-1 drugs due to appetite suppression), the body increases muscle protein breakdown to meet energy demands

The swelling may occur in the arms, legs, hands, ankles, and feet

[DOI] [PMC free article] [PubMed] 272.La A, Nguyen T, Tran K, Sauble E, Tu D, Gonzalez A, et al

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