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Individuals with a history of medullary thyroid carcinoma (a rare neuroendocrine tumor known as MTC) or multiple endocrine neoplasia syndrome type 2 (a hereditary cancer known as MEN 2) should not take semaglutide due to an increased risk of thyroid C-cell tumors in rodents

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Patients taking the 10mg dose typically excrete about 70 grams of glucose per day this way, which accounts for the blood sugar reduction and modest weight loss seen in clinical trials