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The Diabetes Prevention Programme trial showed that metformin reduced weight by approximately 23% of baseline body weight in individuals with prediabetes, which was less than lifestyle intervention alone

Keep Your Gut Balanced While Your Diet Becomes More Intentional Eating less and with less variety shifts your gut microbiome, especially as digestion slows on a GLP-1

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These medicines were invented as an alternative way to treat type 2 diabetes because of the drugs capabilities to regulate blood sugar levels and control appetite

Conclusion: Use of GLP-1RAs was associated with higher 18-month risk for ION than use of SGLT2is and DPP4is, although absolute risk remained very low