Since the majority of the included studies [12, 4345, 47] followed a protocol that favoured titration of GLP-1RAs to the highest optimal doses that patients could tolerate, this may account for the similarity in the incidence rate of GI side effects between KTRs and the general population
Conclusion: Precision or Peril The GLP-1 market is a $150 billion opportunity, but it is no longer a free-for-all
[5] SURMOUNT-4 ran the same experiment with tirzepatide and got the same answer, a 21% average loss largely surrendered within a year of stopping
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Besides, there are indications that a folic acid deficiency leads to a reduced creatine biosynthesis and thus plasma concentration of creatine will decrease 32
