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Programmed cell death in animal development and disease

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However, during the chronic inflammation, the glial activation causes an increase of ROS production and other neurotoxic mediators, leading a neuronal damage [52]

In the PCZ group, the reduction in catecholamine requirement was associated with an increase in Ang II concentration and prevention of the increase in Ang I/Ang II ratio seen in the septic control animals, as assessed by a mass spectrometry method