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Glucocorticoids bind to cytosolic glucocorticoid receptors and regulate gene expression by interacting with glucocorticoid response elements (GREs) in gene promoters

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6.2 Linking GSH/GSSG to Transcriptomic and Proteomic Regulation Transcriptomic and proteomic data can connect metabolite changes to functional modules: GCLC/GCLM/GSS for synthesis, SLC7A11 for substrate acquisition, GSR/GPX/GST for regeneration and use, pentose phosphate pathway enzymes for NADPH supply, and NRF2-KEAP1 signaling for coordinated antioxidant adaptation