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Notably, dietary addition of the HMGCR inhibitor lovastatin (0.02%) restores CYP51A1 expression, suggesting that CYP51A1 is an important component of the feedback loop regulating hepatic cholesterol biosynthesis via HMGCR modulation [36]

J Cutan Med Surg

Older adults may have slower digestion and changes in gut motility, which can increase the likelihood of experiencing gastrointestinal side effects such as stomach cramps

52,54-56 A three-month study of a supplement containing a mixture of curcuminoids (at 0.43 mg per 1,000 kilocalories in the diet) plus hydrolyzed collagen and green tea extract in 42 adult dogs with osteoarthritis found the supplement did not improve lameness or owners subjective assessment of mobility, but significantly reduced veterinarians subjective assessment of pain upon movement of affected limbs