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In patients with AD, an increase in astrocyte-derived circulating exosomes has been observed, which transport proinflammatory cytokines, supporting the idea that reactive astrocytes contribute to inflammation 56

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MOTS-c is a peptide derived from mitochondria, encoded by the mitochondrial genome, and is studied for its role in cellular energy regulation and metabolic signaling

Moreover, macrophage-driven foam cell formation might be increased by the interaction between homocysteine thiolactone and LDL (McCully, 1996

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