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A separate 2025 narrative review by McGuire and colleagues asked a blunter question in its title: "Regeneration or Risk?" [2] Their conclusion: the preclinical evidence is consistently positive, but the absence of human data makes it impossible to generate evidence-based practice guidelines

Men on clomiphene citrate reported adverse events (depressive thoughts, weak muscle strength, gynecomastia, mood changes, agitation, or changes in estradiol or hematocrit levels) 18.18% of the time compared to just 3.45% of the time for patients on enclomiphene

doi: 10.2174/1871527315666160321104303 96 KirkpatrickB.FentonW

Recent studies show that CoQ10 supplementation may improve ovarian response, increase the number and quality of retrievable eggs and support better embryo development in IVF cycles

D., & Edden, R