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Leukocytes, T lymphocytes, B lymphocytes, and macrophages infiltrate the CNS via a compromised BBB, targeting myelin and perpetuating the cycle of inflammation and demyelination

When the MCD enzyme is defective, it can lead to abnormal levels of malonyl CoA, which in turn can impact brain CPT1 and contribute to abnormal brain development

The enzyme cholinephosphotransferase catalyzes this reaction, leading to the formation of phosphatidylcholine and the release of CMP (cytidine monophosphate)