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doi: 10.1016/s0092-8674(00)80434-1

The best outcomes happen when these medications are used together with planned lifestyle adjustments

However, the main reason for this is likely the slower movement of food and acid through the digestive system rather than the stomach making more acid

(34) Experimental and clinical studies demonstrate that GLP-1RAs reduce the production of proinflammatory cytokines (e.g., TNF- , IL-6, Interleukin-1 - IL-1) and chemokines (e.g., Monocyte Chemoattractant Protein-1 - MCP-1, CXCL10), while increasing anti-inflammatory cytokines such as Interleukin-10 (IL-10)

Furthermore, retatrutide has been shown to improve lipid profiles, with reductions in total cholesterol, LDL cholesterol, and triglyceride levels