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The 15 mg dose of tirzepatide produced a mean percent change in weight of almost 21% by week 72, which, when youre talking about a mean baseline body weight of 105.6 kg in that group, is a LOT of kgs dropped

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In the docking analysis with the GLP-1 receptor, it can be seen that the nGLP1-DARPin fusion protein had a higher binding affinity to the GLP-1 receptor (G = 6.1 kcal mol 1 ) compared with the mGLP1-DARPin-1 (G = 5.5 kcal mol 1 ) and mGLP1-DARPin-2 (G = 5.8 kcal mol 1 ) fusion proteins (Table 3, Fig