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Absorption varies greatly between individuals 3

J Am Coll Cardiol 69(5):538540 Premer C, Wanschel A, Porras V, Balkan W, Legendre-Hyldig T, Saltzman RG, Dong C, Schulman IH, Hare JM (2019) Mesenchymal Stem Cell Secretion of SDF-1 Modulates Endothelial Function in Dilated Cardiomyopathy[J]

Cobb, J

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Two complementary lineagessystem Xc inhibitors and GPX4-directed agentsoffer improvements in potency, stability, or solubility, yet translation is constrained by on-target depletion of cystine and glutathione in normal tissues and by off-target perturbations, including mitochondrial channel engagement and p53 pathway modulation, which collectively narrow the therapeutic index