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Aggregation occurs when individual peptide molecules clump together into insoluble complexes, typically triggered by temperature fluctuations, mechanical agitation, or freeze-thaw cycles

10.1210/en.2011-1795 [DOI] [PubMed] [Google Scholar] Daniels, D

The Honest Framing on Melasma If your concern is melasma, read this part twice: melasma is a chronic, recurring condition, and no treatment including this one cures it