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However, we did find a small increased risk of NAION with exenatide use when using the specific NAION definition. Future research should incorporate ocular risk factors or examine dose-dependent effects to continue to investigate a potential causal relationship between semaglutide and NAION, they added

Individual needs vary based on age, weight, and health conditions

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The changes in renal function that are common after trauma and major surgery may lead to several-fold changes in the plasma concentrations of these substances (125), which renders the reliability of these markers questionable

That's why tamoxifen historically became the default endocrine therapy in this setting