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Importantly, extracellular glutamate levels are tightly regulated, as their overabundance at synapses are inked to glutamate-induced excitotoxicity, a condition caused by elevated extracellular brain glutamate concentrations combined with excessive glutamatergic stimulation, resulting in surges in intracellular calcium levels and the initiation of neurotoxic signaling pathways, that are implicated in several neurological pathologies, including neurodegenerative disorders 6,8

Endocrine 73(3):609616

While B12 is available in oral supplements, absorption can vary greatly

GCH1 can also protect cells against oxidative damage by protecting CoQ10