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Pegloticase (trade name Krystexxa), is also a tetrapeptide that is an intravenous drug used to treat hyperuricemia in patients that do not respond well or cannot tolerate other forms of gout treatment.

However, there was a research finding that periodontitis driven by pathogens like P.g causes periodontal microbiota dysbiosis and systemic insulin resistance without major gut microbiota alterations (Blasco-Baque et al., 2017)

Biochim Biophys Acta 1830: 3670-3695

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NFE2L2 can regulate the expression of related genes by transactivation to limit oxidative damage during ferroptosis, and the NFE2L2 signaling pathway is an important defense mechanism against ferroptosis