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Incubations of either lysate or supernatant containing L68Q-hCC with reducing agents glutathione or N-acetylcysteine (NAC) break oligomers into monomers

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The Pesticide Handbook (35) reports that the solubility of Niclosamide at pH 6.4 as 1.6mg/L (which is 4.89uM) and at pH 9.1 is 110mg/L (which is 336.3uM), suggesting that the solubility of niclosamide can vary by at least a factor of almost 100x depending on pH between 6.4 and 9.1