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Hepatocellular carcinoma in a case of adult-onset type II citrullinemia

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According to a small study conducted in 2018, people having insulin resistance are supposed to have lower glutathione levels, especially if they have complications, including retinopathy or neuropathy

Notably, a significant decrease in the expression of gnd , which is pivotal for NADPH production and thus essential for maintaining cellular redox homeostasis and GSH levels, was observed in the GR mutant compared to the WT strain (Figure 4A), suggesting that GR knockout leads to important alterations in metabolic processes, particularly carboxyltransferase activity and carbohydrate metabolism, consistent with our earlier observations