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Undeniably, Ca 2+ fluxes are crucial for almost all reported RCD pathways in erythrocytes, whereas in apoptosis, Ca 2+ elevation mediates primarily the mitochondrial outer membrane permeabilization (MOMP), triggering the intrinsic apoptosis [192]

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Generic copper peptides may include unrelated sequences (e.g., GHK alone without copper, or longer peptides with copper attached post-synthesis) that do not replicate GHK-Cus transcriptional effects