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The protection appears to result from the peptide's ability to bypass inhibitory IGFBP interactions, allowing more effective activation of IGF-1 signaling pathways that enhance sarcolemmal stability and reduce membrane damage during eccentric contractions

Target Engagement Unlike many regulatory peptides that function through a single well defined receptor, BPC-157 appears to interact with multiple molecular components involved in vascular and connective tissue signaling

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405:701-714 [PubMed: 40020703] 15