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COP1 Y491 and H578 form hydrogen bonds with c-Jun Q230 and M235 respectively

Furthermore, depletion of GSH, using l-butathione sulfoximate (BSO) 14,15 and TP219 16 , blocks the assembly of protomeric units into pentamers 14,16,17

In serum of women with endometriosis, the concentration of iron is significantly increased by 1.98-fold (103), and it is highly likely that the iron concentrations at local implant sites are elevated even further

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6 Future directions and clinical perspectives Despite significant advances in delineating the role of eryptosis in the pathogenesis of renal anemiaincluding its regulation by uremic toxins (e.g., indoxyl sulfate, acrolein, oxidative stress, and inflammatory mediatorscritical gaps remain in translating mechanistic insights into clinical practice, presenting several promising avenues for future research