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It was shown that increased HO-1-derived CO production has a vascular protective effect on T1DM, reduces endothelial cell fragmentation, and decreases ICAM-1, VCAM-1 expression, and Caspase-3 activity [122]

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This induction often occurs via activation of Nrf2 (Nuclear factor erythroid 2-related factor 2), a key transcription factor in the antioxidant response pathway

Certain minerals and medications can interfere with glutathione absorption