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Quick Take & Core Data: Average body weight reduction: 30.3% at 104 weeks [1] Dose cohort outcome: 45% of patients in the 12 mg group lost 30% or more body weight [1] Diabetic weight loss efficacy: 16.8% reduction over 40 weeks [2] Retatrutide is a triple agonist that binds directly to three metabolic pathways [1, 3]

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Active transport of bile acids from the lumen into the enterocyte occurs through an apical sodium-dependent bile salt transporter in the brush border

The establishment of standardized protocols for biomarker assessment in clinical settings remains an ongoing challenge

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