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The expression of HO-1, a cytoprotective enzyme critical for heme protein metabolism and ferroptosis, was also highly expressed in iron-accumulating renal cells and in mice with hypertensive nephropathy [257, 260, 261]

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These regulons are termed pasevarions (phase variable regulons) and are implicated in strain differences in virulence traits (Srikhanta et al., 2005

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